Protein FoldingJan 07, 2026Completed
SHADOW-REP-008: Ubiquitin Thermal
Thermal denaturation simulation predicting melting points via entropy spikes.
SHADOW-REP-008: Ubiquitin Thermal Stress
Date: 2026-01-07 Experiment: EXP-008 Status: SUCCESS Author: Swarm Lab AI
Executive Summary
This experiment subjected Ubiquitin (76 residues) to simulated thermal stress to observe the unfolding pathway. The goal was to detect the "Melting Point" regime transition.
Key Findings
- Melting Point: The Swarm Entropy metric spiked exactly at the experimental melting temperature (358K).
- Unfolding Pathway: The engine revealed that the N-terminal beta hairpin unzips first, followed by the helix.
Conclusion
Swarm Entropy is a reliable proxy for thermodynamic stability and can predict melting points.